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Where to download Protein-Protein Interaction Network with Cost values (Or Calculate)?

Hello everyone, I need to build a protein-protein interaction network (Mus musculus) with costs. Actually I will use this interaction network for PCSF package of R.

I checked STRING data base. I downloaded Mus musculus data and it has a combined score column. Is it same with cost? Also all protein names have ENSEMBL ID. I need Protein names (GeneSymbol) for node names.

Where can I download this type of network?

P.S: Is there a way to calculate cost from topology of a network? I think costs are experimental values but I thought there has to be a way to calculate it.

Thank you.

string ppi network
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written by hkarakurt hkarakurt

What do you mean by "cost?"

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written by ejm32 ejm32

With cost I mean edge weight.

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written by hkarakurt hkarakurt

Edge weight can be anything you want. StringDB has many scores based on different types of evidence (text-mining, evolution, co-expression, biochemical interaction, etc.), all of these scores represent the confidence in the interaction bewteen the two proteins/genes. To your second question you could use something like edge betweenness but that has a completely different meaning than stringDB's scores.

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written by ejm32 ejm32

Thank you for your answer. The "cost" they gave is between 0 and 1. Probably they normalized it. Also, I downloaded coexpression network from GeneMania database and it has its own scores (About 12 million interactions actually so it is hard to manipulate). I hope with cost they meant edge weight.

Thank you again.

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written by hkarakurt hkarakurt

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