Thanks for suggesting conda. I installed it. It's really useful to keep such an environment for hassle free software installation.
Update samtools to the latest version
Apologies if this has already been answered, but if I want to update samtools 1.3 to the latest release, what's the best way to go about it? Uninstall the older version first and then do a fresh install, or is there a update command that automatically does that from the terminal?
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Remove the old version and install the new one (or just install the new one over top). But really, as Wouter mentioned, conda is your friend: conda install -c bioconda samtools. I recommend making a separate conda environment for each software version, since then you don't have to worry something breaking because you've accidentally up/down-graded some random dependency of another tool.
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I'd suggest you start using conda, then everything becomes lots easier.