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two genes within same genomic region

Hello,

Gene 1:

NM_001003692 ZMAT5

chr22:30,126,945-30,163,000(GRCh37/hg19)

Gene 2:

NM_182527 CABP7

chr22:30,116,073-30,127,828(GRCh37/hg19)

Ref: http://www.genecards.org/

For these two genes, we see that, CABP7 is overlapping with ZMAT5, is this unusual? Thank you for any hint!

gene genome
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updated by michael.ante michael.ante • written by mike • mike

2 answers

That happens quite frequently so it's not too odd.

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written by WouterDeCoster WouterDeCoster

Hi Mike,

These two genes are on different strands of the chromosome. This is quite usual and nothing to worry about.

Cheers,

Michael

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written by michael.ante michael.ante

Great. Thanks a lot!! What if a CpG site (DNA methylation) can map to two genes? I have seen this issue as well. 

 ID        Genome_Build CHR UCSC_RefGene_Name
 cg27018124           37  22              HPS4
 cg27018124           37  22              SRRD
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written by mike • mike

A CpG site will affect transcription from both the sense and anti-sense strands.

Just to clarify, too: 2 different genes can be transcribed at the same position on both the sense and anti-sense strands, and also one can have overlapping genes on the same strand that have different TSS and/or promoters.

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written by Kevin Blighe Kevin Blighe

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