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What's everyone's take on MSC (Mutation Significance Cutoff)?

Hiya, Computational Biology undergrad in an asian university.

I was wondering if anyone has experience with MSC. Wanted to know if it actually is better than SIFT and Polyphen like it's being reported. I was surprised SIFT and Polyphen was reported as being so horribly inaccurate I wanted to know how people actually thought of MSC -- which the paper is saying is infinitely superior.

snp

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