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Ori-Ter normalization [Chip-seq]

Hello Biostars,

Today I encountered a new terminology called 'Ori-Ter normalisation' . Can anyone explain me what it is and how it can be done? I just came to know somehow the chip-seq peaks near Ori & Termination site will be more, so it has to be normalized. I was using macs2 for peak calling , does it take care of ori-ter normalisation?

Please help me out..

chip-seq normalize next-gen

Are you working on bacteria?

Yes.. more specifically, mycobacterium smegmatis.

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