Rare variant analysis
I started doing some rare variant association analysis tests like burden tests and other types. Some methods say whether it suits risk-increasing and risk-decreasing variants . I don't understand what is the meaning of risk increasing versus risk decreasing variants? Thanks
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WouterDeCoster
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Sharon
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Sharon
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Well, ehm, to me it's pretty self-explanatory:
- a risk-increasing variant increases your risk to get a certain disease
- a risk-decreasing variant decreases your risk to get a certain disease
Does that help? What's unclear exactly?
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WouterDeCoster
Yes - that's what it means. In that case, if you have both risk-increasing and risk-decreasing variants your test will not work.
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