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how to calculate p value

I have two ChIP-seq data, including Case and Control sample. The reads in ChIP-seq followed Poisson distribution, so how to calculate the difference and p value in peaks identified in ChIP-seq.

rna-seq chip-seq r

I need to calculate the difference of two ChIP-seq, not one ChIP-seq and input

Please explain your experimental setting and data better in your question by editing it. What is the difference between doing case-control and case-background analysis?

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