I want to use 16s rRNA sequencing data to predict human gut microbiome metabolic pathways. In some researches, people use computational method the establish genome-scale metabolic reconstruction to study genotype-phenotype relationship. So, is that possible to use 16s rRNA sequencing data to predict human these kind of metabolic pathways? Is there any tools that I can use to help me to achieve this goal? Any useful suggestions would be appreciated.