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Difference between Alignment quality and Mapping quality

I want to ask is there any difference between alignment quality and mapping quality of BAM file ??

sequence bam next-gen

1 answer

Alignment score is the quality of of matching between the read-sequence and reference-sequence. Mapping quality is the confidence that the read is correctly mapped to the genomic coordinates. For example, a read may be mapped to several genomic locations with almost a perfect match in all locations. In that case, alignment score will be high but mapping quality will be low.

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