2 answers
This is an article where it shows gene body methylation has opposite effect on gene expression compared to promoter methylation.
Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer
This is the article where they show it in more systematic way.
Yes, gene body methylation (at least in some cases) seems to stabilize transcription, thereby increasing expression.
Correct, promoter methylation will generally decrease expression while gene body methylation will generally increase it.
does not it also refer to if the methylation is hyper or hypo? based on that the expression of the gene is more or less active or repressed?
In this context, "methylation" will always be "hypermethylation".
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The impact of DNA methylation of different regions?
written by -IvanWoo- •
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Understanding the Impact of DNA Methylation on Gene Expression in Different Genomic Regions
written by Irene •
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RRBS Methylation integration with RNA-seq differential expression
written by Baylie_321 •
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Methylation at probe level and gene expression correlation
written by Will •
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Identifying gene parts based on genomic regions
written by niutster
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Converting regions based on gene start , body , end site ,... to promoter ,exon, intron
written by niutster
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Probes of Human methylation 450 k
written by niutster
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Filtering DMRs
written by niutster
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Effects of some especial non-coding regions
written by niutster
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How to find CpG island shore?
written by achamess
