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The cause of frameshift mutations

Hi!

Indels cause frameshift mutations.

Can a missense mutation cause a frameshift, such that a mutation results in the sequence AUG to be present earlier in the transcript than the start codon.

Thanks!

genome

That would be called a "start gain" mutation I guess and could indeed lead to a shifted reading frame if the new start codon is out of frame, most likely running in a PTC a bit downstream. But start of translation needs more than just a start codon.

But this is not exactly a bioinformatics question and might be closed for that reason.

Hello jh!

We believe that this post does not fit the main topic of this site.

Not related to bioinformatics

For this reason we have closed your question. This allows us to keep the site focused on the topics that the community can help with.

If you disagree please tell us why in a reply below, we'll be happy to talk about it.

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