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Forum: Segmentation method comparisons: HMM, CBS, RS

Hi All,

Segmentation processing is quite important in CNV and DMR analysis. However, is there any paper to compare the power for the difference methods? How many Segmentation method could be applied? I only know HMM, CBS, Rank Segmentation, is there any other popular methods?

Regards

hmm segmentation cbs
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updated by Ram Ram • written by Shicheng Guo Shicheng Guo

1 answer

Well, DSS only looks for consecutive CpGs which reach a certain p-value, though thats also a HMM to some degree.

The review I have most of my information from is Robinoson et al. 2014: (Statistical methods for detecting differentially methylated loci and regions). If you have more I would also be interested.

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written by Aerval Aerval

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