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What up-to-date methods/tools are available for ontology analysis from sequence data?

I've been working on some core genome stuff lately, via OrthoMCL, and have begun to separate out genes based on their 'core-ness' (i.e. are they paralogous, soft-core, full-core and so on).

I'd like to profile the genes remaining in these datasets. For instance, how many of the 2400+ genes that are reported as core are involved in e.g. metabolism, virulence, DNA replication and so forth.

What sorts of programs/tools are available - and ideally reasonably up to date - that could give me something like this?

Some that I'm familiar with, like DAVID, GO, KEGG etc are seemingly getting a little out of date, and can be very picky about what database identifiers you need etc. A colleague mentioned Scoary as an option, but as I didn't do the analysis with Roary, I would have to manually build the presence/absence CSV file it uses as an input, and still, that doesn't give me ontology/pathway analysis as far as I'm aware.

genome gene pangenome

OrthoDB is constantly updated, and provides a number of tools, precomputed files and an API to access the data.

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