Bioinformatics project involving the study of theta- defensin

Question

[ammy22222222]

I'm new to bioinformatics and I'm currently studying the bioinformatics course featured on Coursera. I have come across a subject involving the presence of a defensin (specifically theta -defensin) present in old world monkeys that, in short terms; fully prevents the infection of a host by HIV-1.

By reading further I have learned that the gene which codes for the concerning peptide is in fact available in the human genome, though a premature stop codon prevents the peptide from fully forming. I am very much interested in further studying computational aspects of the matter. Would anyone know any active projects or cited research papers working on activating such a gene or the inhibition of ERF1 (protein responsible for recognition of the stop codon) in that specific area? I have a strong background in machine learning and pattern recognition studies and have recently developed a huge liking to the studies of bioinformatics. First time writing a post here any help and/or advice would be very much appreciated!

[karl.stamm]

You forgot to ask a question. Musings of biology are fun, but we're here to help with technical questions. Maybe you want to just browse over here: https://www.ncbi.nlm.nih.gov/pubmed/?term=applications+of+crispr

Answer 1

[harold.smith.tarheel]

For research papers in this area, try PubMed. For example, searching 'HIV ERF1' returns several references.

[ammy22222222]

thanks for the reply, though most researches are pure biology and i have no idea on how to turn the problems computational. i know my questions are ambiguous i'm just really lost :D