Hi everyone, I'm analyzing the WGBS data and found the software metilene could identify the DMR between groups. But I don't know what input files does the software metilene accept/require, if there are somebody could send me an example. Thank you very much.
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Yeah the documentation isn't so great there. The basic format is what is shown in section 4 of the manual.
So firstly, I need to get the absolute methylation ratio for genome postion for all samples using another softwre, right?
Correct. You can get that with PileOMeth or whatever methylation extractor happens to come with the aligner you used.
Thank you very much. BTW, do you know the difference between the input files of DMR de-novo annotation and that of DMR annotation in known features?
I don't, sorry. If it's not clear from the documentation then you can email the authors.
Ok, I will. Thank you very much
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