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Protein Domain Ontology

I am looking for ways to get started on the following:

Input: protein sequence or open reading frame nucleotide sequence 1. find all domains in the protein sequence 2. for each domain, map it to domain ontology 3. compute the distance between 2 ontology terms

can anyone provide hint?

ontology protein domain pfam tigrfam uniprot

Maybe I am missing something, but what ontology do you want to use in first place?

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