Input into GO in such a way as to not receive ambiguous identifier warnings
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7.7 years ago
LauferVA 4.2k

I have the following list of genes:

ABHD6 ACOXL ANXA3 ARAP1 ATG5 ATM BLK C1QBP CASP8 CCL19 CCL21 CD226 CD5 CD83 CDK2 CDK4 CEP57 CFLAR COG6 CSF3 CTLA4 DNASE1L3 ETS1 FADS1 FADS2 FADS3 HLA-DRB1 ICOSLG IFNGR2 IKZF3 IL20RB IL2RA IL6R ILF3 INPP5B IRAK1 IRF4 IRF5 IRF8 JAZF1 LBH LY9 MMEL1 MYC PADI4 PLCL2 PLD4 PRKCH PRKCQ PTPN11 PTPN2 PTPN22 PTPRC PXK RAD51B RAG2 RASGRP1 RCAN1 RTKN2 RUNX1 SH2B3 SPRED2 STAT4 SYNGR1 TEC TNFAIP3 TNFRSF14 TNFRSF9 TXNDC11 TYK2 ZNF438

They were listed as ambiguous by http://go.princeton.edu/ . Many of these are definitely official gene symbols, I checked.

What I would like to get is a procedure to convert these to any format that GO will recognize as unambiguous. I was thinking DAVID might be able to do this, but was hoping to ask if anyone had experience starting from the gene symbol and finding a way to identify each one well enough to enter it into the enrichment analysis.

GO reports that it accepts "GOA," "GOA + Ensembl Xrefs," and "GOA + HNGC Xrefs," so I suppose the output format would have to be one or more of those.

Thank you.

GO gene symbol HGNC • 1.3k views
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7.7 years ago
EagleEye 7.5k

Try with GeneSCF. It accepts gene symbols one per line in plain text format, example. Please also check this post.

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