Mutation frequency in cancer for a particular gene

Question

[bzhtgb]

Hi all,

There are several dataset in cancer field to compare frequency of mutated genes in patient tumor (TCGA, ...). With these data, we are able to say, ok, geneA is more mutated than gene B, ...

But for a specific gene, is it possible to find frequencies of mutations in a specific position. The goal is to say, ok, for gene1, missense mutation in position 100 is more frequent than mutation in position 200...!

I try to find data but for my gene1, in pos100 there is two case in 2000 tumor human samples, in pos200, only one case.... in conclusion, not enough data to compare these mutation in term of frequencies

I am not an expert of onlcogic database,so do you know if it's possible to answer to this type of question? If yes, have you some examples? Which database to use?

Best!

Answer 1

[igor]

COSMIC has exactly what you need: http://cancer.sanger.ac.uk/cosmic

[bzhtgb]

Thanks Igor,

Unfortunately, I have already check my mutations of interest in COSMIC and there is to few data to allow comparison! (in the case of my sets of mutations...but for others amino acid position in my gene, there is a lot of data ..)

That's life!

But now I am convinced that COSMICS is the main database for this type of query, (completed with a checking in ICGC and TCGA).

Another question, are there a curated database of mutation in cancer induced by a specific type of treatment/ oncologic drugs?