How to convert Hi-C contact frequency into contact probability that is purely between 0 and 1?

Hi,

I wanted to convert my hi-c contact data into purely contact probability like between 0 and 1. What method should i apply? I see a large number in diagonal of matrix. What is the meaning of self contact in hi-c data. Should i discard the diagonal entries to analyzing hi-c or should we keep?

hic genome contact 3c 4c

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written 10.3 years ago by ankitplusplus •

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