Normalization of Hi-C data

Hi everyone,

Does Hi-C data normalization technique depends upon the sequencing depth? Can any one suggest me which normalization will be best for high coverage (around 40X) and low coverage (< 5X).

sequencing next-gen genome

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updated 10.3 years ago by Ryan Dale

• written 10.3 years ago by ankitplusplus •

1 answer

I don't have a direct answer for your question, but you might want to check out HiFive (paper, github) which has three separate normalization strategies you can apply alone or in combination.

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written 10.3 years ago by Ryan Dale

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