mutation signature in cancer
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EMu (C++)
Mutational Signature Framework (Matlab)
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poisonAlien
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I don't think you will get any useful responses unless you explain a little bit more about your research rationale, study design, hypothesis etc.
sorry, but I think I was pretty clear! It doesn' t have to describe the rationale and my whole study to get an answer on that!
I just need a tool to detect snv signature in cancers samples, like in that image below
What people mean with a mutation signature varies a lot. I see that after you have explained that you mean the signatures defined by cosmic you got a useful answer. But still it is unclear for example whether you managed to process reads to variants, which is required input for the suggested programs.