Thanks for the help..
I have SNP IDs in this format: rs3094315, rs3115860.
Now, I want to map these snp ids to gene symbols in which this snp is present.
Can some one help me in this?
4 answers
Probably this may answer your question:
How To Map A Snp To A Gene Around +/- 60Kb ?
Else, just have a look at this blog and also comments where they have talked about various methods.
http://www.gettinggeneticsdone.com/2011/06/mapping-snps-to-genes-for-gwas.html
If you SNP ids aren't huge, you can try some web based tools like: http://pfs.nus.edu.sg
Or use the perl modules or downloads from UCSC browser (explained in the blog and also in the biostar link I have provided)
+1 for completion.
The database dumps from dbSNP have those mappings. Of interest are the organism-specific SNPContigLocusID tables on their ftp server.
The most recent one for human could be found here:
Hi Chris - could you provide a URL to this resource?
The most recent one for human could be found here: ftp://ftp.ncbi.nih.gov/snp/organisms/human_9606/database/organism_data/b135_SNPContigLocusId_37_3.bcp.gz
If the number of SNPs you need to check is small the easiest way is to use dbSNP (http://www.ncbi.nlm.nih.gov/projects/SNP/). If you need to do it in a script and you have the position of the SNP you can just compare it with tx_start,tx_end info that you can download from UCSC. Just be careful to use the same genome version for both your SNP position and the gene position.
To map the SNP to gene, i am using UCSC to get the trans start and end but i am not getting the info for all of my gene list. Please tell from where i can get the trans start and end for most of the genes.
Thanks
PharmGKB has a resource. However it is not a comprehensive list.
http://www.pharmgkb.org/resources/downloads_and_web_services.jsp
Download rsid.zip.
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Related post: Get gene names from rs SNP ids