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MuTect short read preprocessing

Hi, I am programming to do short read preprocessing for BAM files. I have no idea about how to know if paired-end reads are overlapping and the overlapping region, and the mismatch bases for a read (I know the field MD gives the mismatching position, but I did not understand it. Why it is a string not a numeric array?) Thanks very much for your time.

Best Jing

overlapping pe reads mismatching positions

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