Performance of Ingenuity variant analysis compared with open source tools like ANNOVAR

Question

[ssehztirom]

Hi

has anyone compared the results of Ingenuity Variant Analysis (IVA) with open source tools (like ANNOVAR) and resources (like public HGMD)?

Best
Moritz

Answer 1

[DG]

I haven't, at least not systematically, but really all IVA (and similar tools) offer is ease of use for non-bioinformaticians. In my experience they don't really offer any different annotations, or better sources of annotations, than what you get with Annovar, snpEff, GEMINI, etc.