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Do you mean "decoy"?
Even if that is meant to read 'decoy' I'm not sure the question is answerable
Found little abstract about it on this page http://www.matrixscience.com/help/decoy_help.html. It loosely suggests DECOY search would lead you to screen your alignment results for false positives. It also gives perl implementation of the method(http://www.matrixscience.com/downloads/decoy.pl.gz). But this is been done with peptide sequences. All it does is it checks for random sequences & reverse of the targets & screens them accordingly. Was wondering if it makes sense to impose same rules for DNA sequence search??
This IS a real question. Decoy sequences were introduced by Heng Li and Richard Durbin and the guys at the Broad as part of the 1000 Genomes project. The idea is to add extra sequence (satellite, known BACs, HuRef) to the reference to absorb reads with do not truly belong/map to the reference, but are often mapped there by mappers because that's the best place they can put them. Heng has shown this has the effect of reducing false SNP calls by some (small) percentage. - it's not generally possible to translate back to a reference coordinate, and I dont know what you mean by screening