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Impute2 Custom Reference Panel

Have used Impute2 for imputation with the provided reference panels (mostly 1k) and that has always worked well.

For a certain project, am considering the feasibility of using a "custom" reference panel for a set of samples (~200) that are from a population, which went through a severe bottleneck. I have vcf files from a consortium of sorts that would need conversion to the reference panel format.

1. Are there any existing options/tools to generate the recombination map file to work with my vcf (which I plan to convert to legend and haps format for Impute2)

2. Been trying to search for thoughts/experiences if this "custom" reference panel approach has been tried and the pros and cons that I might be overlooking in my excitement.

Thanks for your insight!

imputation impute2 recombination map reference

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