Dear all,

It is a pleasure to inform the release of THOR a HMM based approach for differential peak calling with replicates.

www.regulatory-genomics.org

THOR provides all pre- and post-processing steps required in ChIP-seq: analysis including: fragment size estimation, input-DNA normalization, GC-bias correction, normalization of replicates, p-value estimation, multiple test correction and strand lag filtering of potential DPs.

best,
Ivan