Hello,

I am new in analyzing expression data (I have a computer science background). My objective is to reconstruct a gene regulatory network. To do so I want to combine different series (If it is possible) from GEO in order to have a larger dataset (with enough samples). So I have to work with raw dat and normalize it by myself. I went on GEO and I find out that there are different type of file : .CELL, .GPR, .CSV, .TXT and so on. Those files have different headers (in the matrix data) : such as "Chx Log Ratio" or ''Chx mean" "Chx Median" etc ; For the .GPR files the headers are for example "F633 Median" or "F543 Median" etc. My questions are:

1. Can I combine several series from GEO (I don't want to perform differentially expressed genes)?
2. Does anyone know any links that explain the different heading depending on the file's type?
3. As I want to normalize the data by myself which columns ( headers) should I consider depending on the file's type?

Thanks you very much.