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genome resequencing across developmental stages

Hi,

When I check the specifically expressed genes across developmental stages, I found that the homologous recombination related proteins were enriched. So I want to know, is there project that resequenced the genome across different developmental stages? It will be interesting to found that the organism have developmental stage specific recombination and gene fusion or structural variation.

Best,
Pengcheng

dna resequencing development
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updated by Ram Ram • written by pengchy pengchy

For which organism and tissue. Gene fusions could certainly be developmental stage specific, as can at least some kinds of recombination (I'm thinking of VDJ recombination, though then the definition of "developmental stage" is being stretched a fair bit).

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written by Devon Ryan Devon Ryan

1 answer

I doubt it. I don't think it's currently possible to sequence the genome of a single (multicellular) organism through development since it would most likely die.

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updated by Ram Ram • written by jotan jotan

very important information. If the samples don't extracted from the same individual, the variation may be caused by the individual differences.

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written by pengchy pengchy

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