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What is the best statistics to rank a gene list for GSEA analysis?

Hi,

I have expression values for around 20,000 genes in 100 different individuals. I need to rank these genes for association with the following parameters:

1) the genotype at a certain locus. This genotype can be homozygous for the two alleles, and heterozygous. The three classes are quantitative variables, as there could be an allelic-dosage effect.

2) the number of tumors developed by each individual (integer value that ranges from 0 to around 30).

What are the best statistics for these rankings?

Thanks a lot!

gsea gene expression

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