rare variant associations due to skewed distribution?
Hi, I have heard that (even a slightly) skewed distribution of a quantitative trait can drive the association of rare variants, I'm not sure what the theory behind it is, can someone explain?
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Tafelplankje
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This is a guess. But if the quantitative trait is on a bell curve and you skew it in one direction, then you may consider the possibility that rare eQTLs are responsible.
For example, assume trait X is skewed and 1% of individuals show < q units of X, the genetic variants responsible for this quantitative shift must be rare to account for these 1% of individuals.
However if you're referring heterogeneity I don't know how to correct for that.
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forget the distribution of quantitative traits. How do you propose performing an association to rare variants anyway?