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Statistically significant TFBS for a particular region

Dear all,

I have two sets of chromatin regions (active and Inactive) and I want to see whether the presence of certain TFs is making the difference. For that I want to scan the active regions for the binding sites and prove that it has significantly higher Binding sites than the random region. Will It be fine If I go head with this? what Kind of statistical methods can I use and If I have to visually show that what Kind of plot would be better?

statistical-significance tfbs

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