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Blast entire proteomes

How long would it take to blast an Entire Proteome to another one? I mean in a normal PC such as the latest mac mini

If anyone of you have done this before, please help me.

I don't know if it would take endless time

The scale of the proteome is normal, I mean, like human proteome about n10k~n100k squences.

Thank you all

proteome localblast blast

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