Resequencing region selection · Biostar

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Resequencing region selection

Hi All,

I have been given some data from a candidate gene resequencing experiment. I have recently noticed that processed transcipts are included in the regions. As far as i understand a processed transcript is not thought to code for protein.
Does any one think this could have any downstream affects on analyses such as burden testing.

Thanks for you time.

exome ngs

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updated 4.1 years ago by Ram

• written 11.3 years ago by smilefreak

1 answer

If you are sequencing DNA, I don't know that protein-coding vs. not is really a major issue in terms of the process of sequencing and calling variants. Determining the functional significance of such variants will be impacted by local annotation (protein-coding vs. not, for example).

• 0 views • link

updated 4.1 years ago by Ram

• written 11.3 years ago by Sean Davis

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