Predicting functional effects of a mutation

I would like to know how to predict the functional effect of a SNP/ mutation given only the codon number and the mismatch.

For example, I only have this information:

gene:p53; codon 244: GGC to AGC, Gly to Ser

codon snp next-gen

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updated 4.2 years ago by Ram

• written 11.4 years ago by jan

1 answer

First, your should know the version of the gene annotation used, and than, calculate the chromosome coordinates of this SNP. AND try this:

SIFT

Polyphen2

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updated 4.2 years ago by Ram

• written 11.4 years ago by Czh3

How do I calculate the chromosome coordinates based on the codon number ? all the introns were taken excluded so I can't just simply use the codon number . Any idea ?

• 0 views • link

written 11.4 years ago by jan

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