Hi there,

I want to select random genes while keeping the expression level similar in both pools.

Pool-A: 5000 genes

GeneIDX1 ExpVal_rpkm

GeneIDX2 ExpVal_rpkm and so on

Pool-B 1000 genes

GeneIDY1 ExpVal_rpkm

GeneIDY2 ExpVal_rpkm and so on

Now I want to select 1000 random genes from Pool-A, which has similar expression level as the 1000 genes in Pool-B.

Any suggestions/helps on how to do this (neatly) will be appreciated.

I am thinking of binning genes (from Pool-B) into different bins based on the expression, then use similar bins on Pool-A. Then from each bin select the same number of genes (from Pool-A) as in Pool-B.

Thanks!