I´m sorry if I was not so clear...
And thanks in advance..
Actually part of my current study sample population was included in a previously GWAS in order to identify SNPs associated with the disease risk (my interested phenotype until then). We found 40 GWAS significant SNP associated with the disease risk.
Now, my global aim is to assess if a weighted GRS model that includes an overall discrimination from those 40 SNPs could better predict not only the risk disease but also with associated clinical characteristics (ex. level of activity of the disease).
However, before this I should calculate an average GRS for each individual, based on my known risk count allele per SNP ( that in the end will allow me do a GRS model with the 40 risk SNPs). For that, should I still use the OR values from the previously GWAS?