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Modeling Of Mirnas

Is homology modelling of miRNAs gives meaningful outputs??

mirna homology
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updated by Biostar Biostar • written by Payal • Payal

1 answer

Yes, homology modelling of miRNAs does give meaningful results and is in fact both used in finding them in (closely related species) and in target prediction across species. As usually with homology approaches you need to be careful.

Some tools combine homology searches with functional miRNA evaluations. For instance miRNAminer http://groups.csail.mit.edu/pag/mirnaminer/

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written by Chris Evelo Chris Evelo

thanku @chris. is the same concept goes with long non coding RNAs too?

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written by Payal • Payal

To be honest I don't know. But one aspect you might want to consider is that when you find conservation to be high the sequencing you are looking at is more likely to be functional. That can be an important piece of information.

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written by Chris Evelo Chris Evelo

Homology modeling will not be useful for most of the RNAs because only few RNA structures are available.

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written by Pappu Pappu

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