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general question about "intra tumor heterogeneity"

Dear All,

I wonder that there are references or any literature about "intra tumor heterogeneity" in cancer types.

Are there some discussion or evidences which cancer type shows the most heterogeneity or vise verse?

Any kinds of comments are very welcome :)

Thanks!

cancer-type heterogeneity
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updated by Ram Ram • written by imagineyd imagineyd

2 answers

The short answer is that in most tumor types, most tumors display some amount of subclonal heterogeneity. It's everywhere, and low-frequency events are not being well captured in our standard 50-100x tumor assays.

Update: I can tell you from personal experience that when looking at close to 1000 exomes from TCGA, most (60%+) have detectable subclonal mutations, and I'd wager that most of the rest just didn't have sufficient coverage to uncover additional low-VAF populations. Very few tumors are actually monoclonal.

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updated by Ram Ram • written by Chris Miller Chris Miller

I think that you can start with these two references:

but I agree with chris miller

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updated by Ram Ram • written by a.polo88 a.polo88

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