Are there any in-silico tools that aid in design and development of therapeutic monoclonal antibodies?
are there any in-silico tools that aid in design and development of therapeutic monoclonal antibodies or fragments of the same ?
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For the immunogenicity/developability assessment step of the in-silico pipeline, there's a free API called ImmunoCheck that might be useful: https://jfinnova.es/immunocheck
It's specifically designed for VHH nanobodies and combines three analyses in one call:
MHC-II epitope prediction (IEDB-based, 8 HLA-DRB1 alleles) Humanization scoring with VHH hallmark residue analysis (positions 37, 44, 45, 47) Full developability profiling (pI, GRAVY, aggregation, chemical liabilities) Complements structural tools like AlphaFold/IgFold — they tell you what the structure looks like, ImmunoCheck tells you whether it's likely to be immunogenic and developable.
pip install immunocheck / API docs: https://api.jfinnova.es/docs