To make it more significant, you can subset on the type of genes, rather than all genes.

So, for a different subset of genes (e.g. genes involved in metabolism etc), then generate a table where each column is a subset of genes and rows are the chromosomes which would output a plot something like this

Or you can actually, plot all chromosomes on x axis (each bar is a chromosome) and bar is divided into different gene subsets, so you can compare it among all chromosomes. For significance, you can apply student t-test on that.