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multiple SRA runs analysis

I am a new newbie to the ChIP-Seq analysis and SRA. I download the ChIP-Seq raw data from (SRX012368), and there are 4 run files.

My question is if i want to do peak calling, should i download all 4 run files and merge/cat them , or choose only one run file.

chip-seq sra runs

1 answer

The four runs are from a single sample/library, so merge prior to peak calling.

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