Wet lab cancer researcher (PhD + 5yr US postdoc) seriously considering transition to computational biology/bioinformatics. Would love to hear from anyone who made a similar switch. Considering next stages of career in India. Have basic R knowledge and experience.
2 answers
Demonstrate your skills by reproducing published research papers. Add these re-analyses to public github repositories and list them in your CV. Branch out into different domains, RNA-Seq, ChIP-Seq, Assembly and across different organisms. Show that you can handle different tasks. In my opinion the ability to demonstrate skill in across different types of analyses is a very strong signal and better than having a few publications.
You should start by analyzing published research from NCBI. Use their native CLI tool to fetch FASTQ datasets and analyze them using R and Python. Use Claude/GPT for the start.
However, if you want to skip coding for first few tries, use Notchbio.app for early tests. I created this tool for free that you can use to analyse rna-seq datsets. Since you're starting, downloading all necessary tools and libraries might be overwhelming for you. Take any bulk-rna seq dataset of human genome and run it through the tool. Within a few minutes, you will have your visualizations. This will give you some understanding into how each step works (without the code) and whats the need or output of that step. When confident, you can switch to R and Python for learning.
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Not sure if you are looking for practical advice or an opinion. For the former - taking your experience in bioinfo (little experience with R) at face value, I would strongly recommend first either getting enrolled in a programming certification course or doing an internship in a lab that combines wet lab and computational approaches. For the latter - as someone who transitioned from wet lab to bioinfo/comp-bio in Masters (now doing postdoc in bioinfo/comp-bio), I would say it is a fun but challenging journey. I imagine it has now become easier with ChatGPT, Claude and other LLMs, but they are two-edged swords. Although the work is still focused on biological systems, the transition is a bit of a learning curve that I would only recommend to those who are really determined