This is a test version of Biostars. For the public version, visit https://www.biostars.org.
Tool: Free web tool: Evo 2 log-likelihood scoring for mutant sequences

Ask a frontier genomic foundation model (Evo2) about your DNA variant ! Get Evo 2 DNA variant log-likelihoods in your browser AskEvo2 : https://huggingface.co/spaces/damigupta/ask_evo2

No setup, no Docker, no GPU, no API keys, no login.

Paste ref and alt sequences : get wild-type + mutant log-likelihoods. Single variant and batch modes available.

Validated against ClinVar: BRCA1 AUC=0.90, MLH1 AUC=0.95, n=200 each. Results are raw Evo2 model outputs (no supervised linear probing or retraining applied).

Runs via a Modal backend, hosted on Hugging Face Spaces

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arcinstitute genomics evo2 model

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