Reporting Imputed SNPs in GWAS
Hello everyone!
I'm curious about the practice of reporting SNPs from imputed data in GWAS studies. Are imputed SNPs typically reported, and if so, how are they validated?
Additionally, what's the rationale behind doing imputation after GSA (Global Screening Array) experiments and reporting Genome-wide significant SNP/ suggestive SNP coming from the imputed data when whole-genome sequencing (WGS) could potentially yield similar results?
I'd appreciate any insights or clarifications. Thanks!
-Aastha
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