Hi, I have a question about the relationship between genes and proteins (or enzymes). \ When I searched the information about them, I found that some proteins were commonly mentioned with the different genes in UniProtKB.\ Here's the example result on the ec.2.7.11.1(serine/threonine protein kinase).
I couldn't understand why there were so many proteins sharing the same name across several genes. \ Can the numerous genes encode the same proteins?\ Or if I misunderstand the result in UniProtKB, can you explain the relationship?
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songyeon0425 •
2 answers
The Enzyme Commission (EC) numbers define enzymatic reactions in a hierarchical manner. In your example, 2. enzymes are transferases, 2.7. correspond to "Transferring Phosphorus-Containing Group", and so on. So these codes are for enzymes, and different genes might encode different proteins with the same enzymatic activity.
Hi,
Although both proteins have the same function, they already differ in size (as given in your screenshot). Looking at their genomic coordinates shows that they are located on different chromosomes/locations.
Deriving from the names themselves, or looking at the 'Subcellular Location' and 'Expression' sections in their entries, you can see that they have a different specificity. Different tissues and different cell compartments have different chemical milieus. It seems it have been evolutionary beneficial to have adapted enzymes for different environments.
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