Led by Avery D. Posey, Jr., Ph.D., the Posey Lab at the University of Pennsylvania Perelman School of Medicine focuses on the development of novel cancer therapies for humans and dogs that genetically alter cancer patients’ own T cells to improve the ability of the immune system to fight cancer. This research involves antigen discovery to identify tumor-specific targets, engineering strategies to surmount the tumor microenvironment, and altering the signaling influences of T cells to develop robust anti-tumor efficacy. Read more: view