Simulation of label-free bottom-up proteomics expression dataset
Are any R-package or methods available to simulate a label-free bottom-up proteomics expression dataset? I have tried 'generate.ExpressionData' function of 'imputeLCMD' R-package. It gives the normalized dataset. I have to test the normalization and imputation approaches on the simulated dataset. For that purpose, the simulated dataset should look like a real-time dataset that does not follow any distribution. Is there any way to do that?
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