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Calculating height prediction from PGS

Hi, I'm trying to get height prediction values from Yengo 2022 paper (https://www.nature.com/articles/s41586-022-05275-y). I downloaded the PGS weights from https://www.joelhirschhornlab.org/giant-consortium-results, which has SNPs and their weights. But, I don't see any formula to derived predicted heights with these weights. Anyone could illuminate on this?

polygenic-score
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updated by Sam Sam • written by fitwae • fitwae

Thanks. I'll check it out.

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written by fitwae • fitwae

1 answer

You don't really get a "predicted" height per-sec, rather, you get a score that has correlates with the height. With the provided weights, you can directly use plink --score to generate the polygenic score, but most likely they won't look like height (e.g. mean 170 in male and 160 in female etc).

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written by Sam Sam

Thanks. Is it linear, as in height = score * (some factor) + (some factor)?

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written by fitwae • fitwae

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