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ConsensusClusterPlus on DEGs

Hello everyone,

I am writing to inquire about the suitability of using the ConsensusClusterPlus clustering method for my 1000 DEG genes (differentially expressed genes) between T (tumor) and normal samples. Additionally, I am considering alternative methods such as K-means for clustering these genes.

I am aware that the WGCNA package suggests avoiding gene filtering before running the method. Therefore, I am seeking guidance on whether it is advisable to proceed with ConsensusClusterPlus or explore other approaches like K-means for this purpose.

Thank you for your attention.

consensusclusterplus degs

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